missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. 10018432

Invitrogen™ Human PPARD, Ligand Binding Domain, GST Tag Recombinant Protein

Product Code. 10018432
Change view
Click to view available options
Quantity:
50 μg
Unit Size:
Each
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
10018432 50 μg Each
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 10018432 Supplier Invitrogen™ Supplier No. PV4694
 Restricted Item
Estimated Shipment: 01-09-2026
Add to basket
Add to basket
This item is not returnable. View return policy

Description

Recombinant Protein

Peroxisome Proliferator Activated Receptor delta, Ligand Binding Domain (PPAR delta-LBD) is a 59.90 kDa recombinant human protein (amino acids 165-441) expressed as a GST-tagged fusion protein in E. coli cells. PPAR delta-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies. Protein Form: Recombinant, Ligand Binding Domain.

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q03181
Concentration See Label
For Use With (Application) Binding Assay
Formulation Proprietary buffer with no preservative
Gene ID (Entrez) 5467
Name Human PPARD, Ligand Binding Domain, GST Tag
Purification Method Purified
Quantity 50 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias FAAR; MGC3931; Nr1c2; NUC1; NUC-1; NUCI; NUCII; nuclear hormone receptor; nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferative activated receptor delta; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR[b]; PPARB; Pparb/d; PPARbeta; PPAR-beta; Ppard; PPARdelta; PPAR-delta; PPARdelta/beta
Common Name PPAR delta
Gene Symbol Ppard
Protein Length 165-441
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence 165-441
Content And Storage Store in ultra-cold freezer (-68 to -85°C).
Shipping Condition Dry Ice
Expression System E. coli
Protein Family Receptors
Protein Form Recombinant, Ligand Binding Domain
Form Liquid
Protein Subtype Hormone Receptors
Research Category Drug Discovery: Neurobiology
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.