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PP2CA/PP2CB Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA112395
Additional Details : Weight : 0.01000kg
Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.Specifications
| PP2CA/PP2CB | |
| Polyclonal | |
| PBS with 0.08% sodium azide | |
| O62829, O62830, O75688, P20650, P35813, P35815, P36993, P49443 | |
| PPM1A, Ppm1b | |
| Synthetic peptide. | |
| 100 μg | |
| Primary | |
| Bovine, Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Western Blot | |
| Unconjugated | |
| Ppm1b | |
| 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; FLJ42306; IA; MGC9201; MMPa-2; Mpp alpha; MPPa-1; Pp2c1; Pp2c2; PP2CA; PP2Calpha; PP2C-ALPHA; PP2CB; PP2CBETA; PP2C-beta; PP2C-beta-X; PPC2BETAX; Ppm1a; PPM1B; PPM1B protein; Pppm1a; Pppm1b; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A, magnesium dependent, alpha isoform; protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C alpha; protein Phosphatase 2C beta; protein phosphatase 2C isoform alpha; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), | |
| Rabbit | |
| Ammonium sulfate precipitation | |
| RUO | |
| 19042, 19043, 24666, 24667, 281994, 281995, 5494, 5495 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |