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PIR-A/B Monoclonal Antibody (10-1-PIR), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

328.00 EUR

Specifications

Antigen PIR-A/B
Clone 10-1-PIR
Concentration 0.2 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15300720
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Affymetrix eBioscience
17-3101-82
100 μg
328.00 EUR
100µg
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Estimated Shipment: 09-04-2024
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Description

Description

Description: This 10-1-PIR monoclonal antibody reacts with mouse paired Ig-like receptors of activating (PIR)-A and -B. These cell surface glycoproteins, which contain six extracellular Ig-like domains with distinct transmembrane and cytoplasmic regions, are expressed together on B lymphocytes, dendritic cells, macrophages, granulocytes, platelets, and mast cells. However, expression of PIR-A/B has not been observed on T cells, NK cells, and erythrocytes. The PIR-A receptor interacts with signaling molecules containing immunoreceptor tyrosine-based activation motifs (ITAMs) which lead to its activating function. In contrast, the PIR-B receptor associates with proteins possessing immunoreceptor tyrosine-based inhibitory motifs (ITIMs); therefore, this receptor has been shown to have an inhibitory function. PIRs bind MHC class I to modulate cell signaling and homeostasis of the immune system. Moreover, PIR-B knockout mice have been shown to exhibit susceptibility to Salmonella infection. Crossblocking studies indicate that 10-1-PIR recognizes a different epitope from 6C1 (cat. no. 46-5978). Applications Reported: This 10-1-PIR antibody has been reported for use in flow cytometric analysis. Applications Tested: This 10-1-PIR antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test.

PIR-A/B Monoclonal antibody specifically detects PIR-A/B in Mouse samples. It is validated for Flow Cytometry.
Specifications

Specifications

PIR-A/B
0.2 mg/mL
Monoclonal
Liquid
RUO
P97484
Primary
4° C, store in dark, DO NOT FREEZE!
10-1-PIR
Flow Cytometry
APC
Rat
Mouse
IgG2b κ
Affinity chromatography
Antibody
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