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PIR-A/B Monoclonal Antibody (10-1-PIR), APC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
328.00 EUR
Specifications
Antigen | PIR-A/B |
---|---|
Clone | 10-1-PIR |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15300720
|
Affymetrix eBioscience
17-3101-82 |
100 μg |
328.00 EUR
100µg |
Estimated Shipment: 09-04-2024 Log in to see stock. |
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Description
Description: This 10-1-PIR monoclonal antibody reacts with mouse paired Ig-like receptors of activating (PIR)-A and -B. These cell surface glycoproteins, which contain six extracellular Ig-like domains with distinct transmembrane and cytoplasmic regions, are expressed together on B lymphocytes, dendritic cells, macrophages, granulocytes, platelets, and mast cells. However, expression of PIR-A/B has not been observed on T cells, NK cells, and erythrocytes. The PIR-A receptor interacts with signaling molecules containing immunoreceptor tyrosine-based activation motifs (ITAMs) which lead to its activating function. In contrast, the PIR-B receptor associates with proteins possessing immunoreceptor tyrosine-based inhibitory motifs (ITIMs); therefore, this receptor has been shown to have an inhibitory function. PIRs bind MHC class I to modulate cell signaling and homeostasis of the immune system. Moreover, PIR-B knockout mice have been shown to exhibit susceptibility to Salmonella infection. Crossblocking studies indicate that 10-1-PIR recognizes a different epitope from 6C1 (cat. no. 46-5978). Applications Reported: This 10-1-PIR antibody has been reported for use in flow cytometric analysis. Applications Tested: This 10-1-PIR antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test.
PIR-A/B Monoclonal antibody specifically detects PIR-A/B in Mouse samples. It is validated for Flow Cytometry.Specifications
PIR-A/B | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
P97484 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
10-1-PIR | |
Flow Cytometry | |
APC | |
Rat | |
Mouse | |
IgG2b κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.