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Musashi-1 Monoclonal Antibody (14H1), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
161.00 EUR - 375.00 EUR
Specifications
Antigen | Musashi-1 |
---|---|
Clone | 14H1 |
Concentration | 0.5 mg/mL |
Applications | Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15248217
|
Affymetrix eBioscience
14-9896-80 |
25 μg |
161.00 EUR
25µg |
Estimated Shipment: 09-04-2024 Log in to see stock. |
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15258217
|
Affymetrix eBioscience
14-9896-82 |
100 μg |
375.00 EUR
100µg |
Estimated Shipment: 07-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: This 14H1 monoclonal antibody recognizes human Musashi-1 (MSI-1), a 39 kDa RNA binding protein. Musashi-1 is expressed in CNS stem and progenitor cells with decreased expression in differentiating cells. Musashi-1 functions as a translational repressor, directly regulating its target proteins, Numb and p21 (CIP1). Musashi-1 has been shown to be expressed in stem cells in a variety of other tissues such as the gut, stomach, mammary gland, and hair follicles. In addition to normal tissue expression, Musashi-1 expression has been identified in cells from several tumor types, mainly pulmonary and adenocarcinoma, as well as large and small cell carcinomas. Recently, expression of Musashi-1 in ischemic lesions following stroke provides evidence for neurogenesis as well as the role of Musashi-1 in regulating apoptosis. Musashi-1 is highly conserved and the 14H1 antibody also recognizes mouse and rat Musashi-1. Applications Reported: This 14H1 antibody has been reported for use in immunoblotting (WB), immunohistology staining of paraffin embedded tissue sections, and immunocytochemistry. Applications Tested: This 14H1 antibody has been tested by immunofluorescent staining of paraformaldehyde fixed and permeabilized cells. This can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE.
Musashi-1 belongs to the Musashi family of RNA-binding proteins which play a role in cell fate determination, and maintenance of stem-cell state. Musashi family proteins are also involved in post transcriptional gene regulation. The gene encodes a protein with two conserved tandem RNA recognition motifs with highly conserved RNP (ribonucleoprotein) motifs. In mammals, Musashi-1 is expressed in fetal kidney, brain, liver and lung, and in adult brain and pancreas. In humans, the gene is located on chromosome 12.Specifications
Musashi-1 | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
fb40b12; hypothetical protein LOC541389; m-Msi-1; ms1; msi1; msi1b; Msi1h; Musahi1; musashi homolog 1; Musashi homolog 1(Drosophila); musashi RNA binding protein 1; musashi RNA binding protein 1b; musashi RNA-binding protein 1; musashi1; musashi-1; RNA-binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1 L+35bp; RNA-binding protein Musashi homolog 1 Long; RNA-binding protein Musashi homolog 1b; wu:fb40b12; zgc:103751; zMsi1 | |
MSI1 | |
Primary | |
4° C | |
MSI1 |
14H1 | |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
Unconjugated | |
Rat | |
Human, Mouse, Rat | |
O43347, Q61474, Q8K3P4 | |
17690, 259272, 4440 | |
IgG2a | |
Affinity chromatography | |
Antibody |
For Research Use Only.