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LRRK2 WT Full Length Protein

LRRK2 WT Full Length Protein

Brand:  Invitrogen A15198

Additional Details : Weight : 0.00900kg

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Product Code. 15393806

  • 1942.00 EUR / 100µg


Estimated Shipment date
from Supplier 23-11-2017
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Disclaimers:

For Research Use Only. Not for use in diagnostic procedures.


Description

Description

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multi-domain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active wild-type LRRK2 protein may be useful in research to better understand the native protein, unaffected by mutations, as well as to explore the mechanisms underlying the disease.

  • Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
  • Uncover novel compounds or hits specific to the full-length form
  • Advance Parkinson's research using the full-length protein and validated assays

    Related Links:
    LRRK2 Tools for Advancing Parkinson's Disease Research
    LanthaScreen™ Kinase Activity Assay
    LanthaScreen™ Eu Kinase Binding Assay
  • Specifications

    Specifications

    NP_940980.3
    Protein assays and analysis
    288kDa
    85% by SDS-PAGE
    –68 to –85°C
    1 Each
    LRRK2 WT Full Length Protein
    Kinase assay
    LRRK
    61nmoles of phosphate transferred to ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 2.08μg/mL
    DYKDDDDK
    0.22mg/mL
    120892
    LRRK2 WT Full Length Protein
    100μg
    For research use only. Not for use in diagnostic procedures
    AURA17, DARDARIN, PARK8, RIPK7, ROCO2
    LRRK2 WT Full Length was pre-diluted in enzyme dilution buffer and assayed in 20mM Tris (pH 7.5), 10mM MgCl2, 1mM EGTA, 1mM Na3VO4, 5mM β-glycerophosphate, 2mM DTT, 0.02% Triton™ X-100, 100μM ATP, 250μM ERM (LRRKtide) peptide substrate (RLGRDKYKTLRQIRQ) (PV5093) and trace [32P]-γ-ATP for 10 minutes at 30°C
    Baculovirus
    LRRK2 WT Full Length Protein
    Human
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