Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, Clone: DATK32 (DATK-32), eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5887-85
Additional Details : Weight : 0.01000kg
DescriptionAggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
|Integrin alpha 4 beta 7 (LPAM-1)|
|PBS with 0.09% sodium azide; pH 7.2|
|ITGB7, Gut homing receptor beta subunit, Integrin alpha-4/beta-7, Peyer patches-specific homing receptor LPAM-1, Itga4|
|Flow Cytometry, Functional Assay|
For Research Use Only.