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Invitrogen™ Human IL-33 Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP0514

Additional Details : Weight : 0.01000kg

Product Code. 15358630

  • 131.00 EUR / 50µg
Estimated Shipment: 12-04-2024
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Description

Description

IL-33 Synthetic Peptide, PEP-0514, from Invitrogen.

IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer′s patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties. This peptide corresponds to 19 amino acids near the amino terminus of human IL-33.PEP-0514 can be used as a blocking peptide with polyclonal antibody PA5-20397.
Specifications

Specifications

90865
purified
Human IL-33
-20°C
Liquid
Blocking Assay, Control
No
Peptide
RUO - research use only
Human
O95760
200 μg/mL
Synthetic Peptide
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
IL33
0.02% sodium azide
50 μg
PBS
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