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Invitrogen™ Human IL-33 Synthetic Peptide
Synthetic Peptide
Brand: Invitrogen™ PEP0514
Additional Details : Weight : 0.01000kg
Description
IL-33 Synthetic Peptide, PEP-0514, from Invitrogen.
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer′s patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties. This peptide corresponds to 19 amino acids near the amino terminus of human IL-33.PEP-0514 can be used as a blocking peptide with polyclonal antibody PA5-20397.Specifications
90865 | |
purified | |
Human IL-33 | |
-20°C | |
Liquid | |
Blocking Assay, Control | |
No | |
Peptide | |
RUO - research use only |
Human | |
O95760 | |
200 μg/mL | |
Synthetic Peptide | |
PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 | |
IL33 | |
0.02% sodium azide | |
50 μg | |
PBS |