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IFN gamma Monoclonal Antibody (CC302), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MBOIFNG

Product Code. 11874311

  • 554.00 EUR / 500µg

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Description

Description

MBOIFNG targets IFN gamma in ELISA, and FACS applications and shows reactivity with Bovine, Canine, Equine, Goat, Human, Mustelid, Ovine, and Porcine samples. The MBOIFNG immunogen is recombinant Bovine IFN gamma. MBOIFNG detects IFN gamma which has a predicted molecular weight of approximately 17 kDa.

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IFN gamma
Monoclonal
1 mg/mL
PBS with proprietary preservative
P01579, P07353, P17773, P17803, P42160, P42161, P79154
IFNG
Recombinant Bovine IFN gamma
500 μg
Primary
Bovine, Canine, Equine, Goat, Human, Mustelid, Ovine, Porcine
Antibody
IgG1
ELISA, Flow Cytometry
CC302
Unconjugated
IFNG
BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
Mouse
Protein G
RUO
100034181, 100860815, 281237, 3458, 396991, 403801, 443396
-80°C
Liquid
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