missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Gibco™ Human FRP-4 (soluble) Recombinant Protein, PeproTech®
CHO cells Recombinant Protein
Brand: Gibco™ 120-50-500UG
Additional Details : Weight : 0.16500kg
Description
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis.Specifications
Q6FHJ7 | |
protein with no preservative | |
37.8 | |
500 μg | |
-20°C | |
<1 EU/μg | |
SFRP4 | |
Unconjugated | |
VRGAPCEAVR IPMCRHMPWN ITRMPNHLHH STQENAILAI EQYEELVDVN CSAVLRFFLC AMYAPICTLE FLHDPIKPCK SVCQRARDDC EPLMKMYNHS WPESLACDEL PVYDRGVCIS PEAIVTDLPE DVKWIDITPD MMVQERPLDV DCKRLSPDRC KCKKVKPTLA TYLSKNYSYV IHAKIKAVQR SGCNEVTTVV DVKEIFKSSS PIPRTQVPLI TNSSCQCPHI LPHQDVLIMC YEWRSRMMLL ENCLVEKWRD QLSKRSIQWE ERLQEQRRTV QDKKKTAGRT SRSNPPKPKG KPPAPKPASP KKNIKTRSAQ KRTNPKRV | |
≥ 95% by SDS-PAGE gel and HPLC analyses. |
Functional Assay | |
6424 | |
Human FRP-4 (soluble) | |
CHO cells | |
RUO | |
Ddc4; DDC-4 protein; Frizzled protein, human endometrium; frizzled related protein; frizzled-related protein; frizzled-related protein 4; FRP; FRP-4; FRPHE; MGC26498; secreted frizzled related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related protein 4; secreted frizzled-related sequence protein 4; Sfrp4; sFRP-4 | |
Human | |
Recombinant | |
Lyophilized |