Ferritin Monoclonal Antibody (523), Invitrogen™

Description

MA5-14735 detects Ferritin in ELISA, IP, IF, and RIA applications and shows reactivity to human samples. The MA5-14735 Immunogen is human liver ferritin. MA5-14735 detects ferritin which has a predicted molecular weight of approximately 19kDa. Product MA514735 is a smaller package size of MIF2503 (formerly sold as a Seradyn product).

Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. Ferritin is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in the light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. The ferritin gene has multiple pseudogenes, and ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. Ferritin is a holoenzyme shell with a molecular weight of about 450 kDa, and consists of 24 subunits of two types, H(heavy) and L(light), and capable of storing up to 4,500 atoms of ferric iron.