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  8. Fenobam, Tocris Bioscience™

Fenobam, Tocris Bioscience™

Catalog Number 18055462
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Quantity:
50 mg
This item is not returnable. View return policy
57653-26-6
C11H11ClN4O2
266.69
MFCD00868019
DWPQODZAOSWNHB-UHFFFAOYSA-N
fenobam, fenobamum, fenobamum inn-latin, 3h fenobam, unii-078rcy7i27, 1-3-chlorophenyl-3-2e-1-methyl-4-oxoimidazolidin-2-ylidene urea, n-3-chlorophenyl-n'-4,5-dihydro-1-methyl-4-oxo-1h-imidazol-2-yl urea, dsstox_cid_26770, dsstox_rid_81892, dsstox_gsid_46770
162834
1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
CN1CC(=O)N=C1NC(=O)NC1=CC=CC(Cl)=C1
This item is not returnable. View return policy
57653-26-6
C11H11ClN4O2
266.69
MFCD00868019
DWPQODZAOSWNHB-UHFFFAOYSA-N
fenobam, fenobamum, fenobamum inn-latin, 3h fenobam, unii-078rcy7i27, 1-3-chlorophenyl-3-2e-1-methyl-4-oxoimidazolidin-2-ylidene urea, n-3-chlorophenyl-n'-4,5-dihydro-1-methyl-4-oxo-1h-imidazol-2-yl urea, dsstox_cid_26770, dsstox_rid_81892, dsstox_gsid_46770
162834
1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
CN1CC(=O)N=C1NC(=O)NC1=CC=CC(Cl)=C1

Description

Potent and selective mGlu5 negative allosteric modulator (NAM)

Potent and selective non-competitive mGlu5 negative allosteric modulator (NAM) that also displays inverse agonist properties; blocks mGlu5 constitutive activity in vitro (IC50 = 87 nM). Acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors respectively. Displays anxiolytic activity following oral administration in vivo; also exhibits analgesic properties.
Quantity 50 mg
Formula Weight 266.69
Percent Purity >99%
Chemical Name or Material Fenobam
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