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Ea52-68 peptide bound to I-Ab Mouse anti-Mouse, Biotin, Clone: eBioY-Ae (YAe, Y-Ae), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5741-81

Additional Details : Weight : 0.25000kg

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Product Code. 15259839

  • 79.75 EUR / 50µg


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Description

Description

Applications Reported: This eBioY-Ae (YAe, Y-Ae) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioY-Ae (YAe, Y-Ae) antibody has been tested by flow cytometric analysis of a mouse strain known to express the I-A^b/MHC Class II:Ea peptide complex. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered. MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
Specifications

Specifications

Ea52-68 peptide bound to I-Ab
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P06342
H-2Eb, H2Eb, Ia-4, Ia4, MGC163794, MGC163796
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
eBioY-Ae (YAe, Y-Ae)
Biotin
H2-Ab1
Liquid
H2-Ab1
IgG2b
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
14961
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