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E-selectin Monoclonal Antibody (1.2B6), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA122165
Additional Details : Weight : 1.24740kg
Description
Not suitable for immunohistochemistry (paraffin). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.Specifications
E-selectin | |
Monoclonal | |
1 mg/mL | |
PBS with 0.09% sodium azide | |
P16581, P98110 | |
SELE | |
Human E-Selectin (ELAM-1) | |
100 μg | |
Primary | |
Human, Porcine | |
Antibody | |
IgG1 |
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot | |
1.2B6 | |
Unconjugated | |
SELE | |
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell | |
Mouse | |
Protein A | |
RUO | |
397508, 6401 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |