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DARPP-32 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA585787
Additional Details : Weight : 0.01000kg
Description
Keep as concentrated solution. Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%). Positive Control: mouse brain, rat brain. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
DARPP-32 is a dopamine (DA) and AMP-regugated ∽32 kDa phosphoprotein that is associated with dopaminoceptive neurons. The protein inhibits Protein Phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regugation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.Specifications
| DARPP-32 | |
| Polyclonal | |
| Unconjugated | |
| Ppp1r1b | |
| AU040756 antibody; Darpp32 antibody; Ppp1r1b antibody; protein phosphatase 1; regulatory (inhibitor) subunit 1B antibody | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 360616, 19049 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot | |
| 1.11 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| Q6J4I0, Q60829 | |
| Ppp1r1b | |
| Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of mouse DARPP-32. | |
| 100 μL | |
| Primary | |
| Mouse, Rat | |
| Antibody | |
| IgG |