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Cytokeratin 8 Monoclonal Antibody (LP3K), FITC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
207.00 EUR - 500.00 EUR
Specifications
Antigen | Cytokeratin 8 |
---|---|
Clone | LP3K |
Concentration | 0.5 mg/mL |
Classification | Monoclonal |
Conjugate | FITC |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15288389
|
Affymetrix eBioscience
11-9938-80 |
25 μg |
207.00 EUR
25µg |
Estimated Shipment: 07-05-2024 Log in to see stock. |
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15298389
|
Affymetrix eBioscience
11-9938-82 |
100 μg |
500.00 EUR
100µg |
In Stock Log in to see stock. |
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Description
Description: This LP3K monoclonal antibody reacts with human cytokeratin 8 (K8), a 55-kDa member of the family of intermediate filament proteins. Cytokeratin 8 is a type II (or basic) keratin that is expressed in epithelial and carcinoma cells. Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues. More specifically, studies have demonstrated the involvement of cytokeratin 8 in protection against apoptosis, stress, or injury, as well as regulation of the cell cycle. This keratin is frequently co-expressed with cytokeratin 18, a type I (or acidic) keratin as a heterodimer. Although detected primarily in the cytoplasm of normal healthy cells, cytokeratin 8 has been found to localize to the plasma membrane in some tumor cells. Finally, cytokeratin 8 is phosphorylated on serine 73 in dividing cells. Applications Reported: This LP3K antibody has been reported for use in immunofluorescent microscopy. Applications Tested: This LP3K antibody has been tested by immunofluorescent staining of methanol-fixed MCF-7 cells. This can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
Cytokeratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. Cutokeratin 8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.Specifications
Cytokeratin 8 | |
0.5 mg/mL | |
FITC | |
Mouse | |
Human | |
3856 | |
IgG1 | |
Affinity chromatography | |
Antibody |
LP3K | |
Monoclonal | |
Liquid | |
RUO | |
P05787 | |
KRT8 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
KRT8 |
For Research Use Only.