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Invitrogen™ CDK1/cyclin A2 Recombinant Human Protein

CDK1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. Recombinant full-length human CDK1 and CyclinA2 were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

Brand:  Invitrogen™ PV6281

Additional Details : Weight : 0.01000kg

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Product Code. 15458933

  • 1180.00 EUR / 100µg


Estimated Shipment date
from Supplier 17-12-2018
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Description

Description

CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
60.4/74.8kDa
Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
Human
GST Tag
50mM Tris-HCl pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
100μg
Kinase Assay
Yes
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