CD95 (APO-1/Fas) Mouse anti-Human, Functional Grade, Clone: EOS9.1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 16-0958-85
Additional Details : Weight : 0.01000kg
Description001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
|PBS with no preservative; pH 7.2|
|ALPS1A, APO-1, APT1, Apo-1 Fas, CD95, FAS1, FASTM, TNFRSF6|
|Flow Cytometry, Functional Assay|
For Research Use Only.