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CD83 Rat anti-Mouse, FITC, Clone: Michel-17 (Michel17), eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-0831-82

Additional Details : Weight : 0.25000kg

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Product Code. 15258139

  • 180.00 EUR / 100µg


Estimated Shipment date
from Supplier 30-07-2019
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Description

Description

CD83 cell surface antigen is a 40-45kD glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express very low levels of CD83 after culture in agents such as Con A or PHA. In immunohistology, CD83 is shown to be expressed strongly by interfollicular interdigitating reticulum cells and more weakly by cells within germinal centres. CD83 is also expressed by Langerhan′s cells in the skin. The CD83 antigen is a 186-amino-acid single-chain glycoprotein and this molecule is a member of the immunoglobulin superfamily that is composed of an extracellular V-type Ig-like single domain, a transmembrane region, and a short, 40-amino-acid cytoplasmic tail. CD83 antigen undergoes extensive post-translational glycosylation, since the determined Mr is twice the predicted size of the core protein. However, CD83+ cells have a unique cell surface immuno-phenotype that does not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. CD83+ cells coexpress the highest levels of MHC class II molecules, when compared with other leucocyte lineages. They also co-express T cell markers (CD2, CD5), B cell markers (CD40, CD78), myeloid cell markers (CD13, CD33, CD36), cytokine receptors as well as other cell surface molecules. Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.
Specifications

Specifications

CD83
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
O88324
Cd83
IgG1
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12522
Flow Cytometry
Michel-17 (Michel17)
FITC
Cd83
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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