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CD31 (PECAM-1) Rat anti-Mouse, PE, Clone: 390, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0311-81

Additional Details : Weight : 0.25000kg

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Product Code. 15258509

  • 89.25 EUR / 50µg


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Description

Description

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Specifications

Specifications

CD31 (PECAM-1)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q08481
CD31 antigen, CD31/EndoCAM, GPIIA′, PECA1, PECAM-1, CD31/EndoCAM, adhesion molecule, endoCAM, platelet endothelial cell adhesion molecule
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
390
PE
Pecam1
Liquid
Pecam1
IgG2a, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
18613
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