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CD31 Monoclonal Antibody (TLD-3A12), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA180069
Additional Details : Weight : 0.01000kg
Description
For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Mouse anti Rat CD31 antibody, clone TLD-3A12 recognizes rat PECAM-1 (CD31), a 661 amino acid type 1 transmembrane protein expressed primarily on endothelial cells, platelets and leucocytes.
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.Specifications
CD31 | |
Monoclonal | |
1 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q3SWT0 | |
Pecam1 | |
Activated, Lewis rat derived microglial cells. | |
100 μg | |
Primary | |
Rat, Rhesus Monkey | |
Antibody | |
IgG1 |
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot | |
TLD-3A12 | |
Unconjugated | |
Pecam1 | |
C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule | |
Mouse | |
Protein A | |
RUO | |
29583, 718302 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |