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CD253 (TRAIL) Rat anti-Mouse, Clone: N2B2, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5951-81

Additional Details : Weight : 0.01000kg

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Product Code. 15287617

  • 99.25 EUR / 50µg


Estimated Shipment date
from Supplier 23-07-2019
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Description

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Specifications

Specifications

CD253 (TRAIL)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P50592
Apo2L (for Apo-2 Ligand), TNF-Related Apoptosis-Inducing Ligand, Tumor necrosis factor ligand, superfamily member 10, TRAIL protein, CD253 antigen, TN
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization
N2B2
Unconjugated
Tnfsf10
Liquid
Tnfsf10
IgG2a, kappa
50 μg
4° C
Primary
22035
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For Research Use Only.