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CD202b (TIE2) Monoclonal Antibody (TEK4), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

109.00 EUR - 475.00 EUR

Specifications

Antigen CD202b (TIE2)
Clone TEK4
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15289979
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Affymetrix eBioscience
13-5987-82
100 μg
233.00 EUR
100µg
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Estimated Shipment: 10-04-2024
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15279979
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Affymetrix eBioscience
13-5987-81
50 μg This item is currently unavailable or has been discontinued.
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15299979
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Affymetrix eBioscience
13-5987-85
500 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The TEK4 monoclonal antibody reacts with mouse Tie-2, also known as CD202. A member of the tyrosine kinase receptor family, Tie-2 is expressed on endothelial and a subset of hematopoietic cells and is believed to play a role in both angiogenesis and hematopoiesis during development of the mouse embryo. In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. Long-term multilineage repopulating cells were detected in Tie-2^+, Lineage^-, c-Kit^+, Sca1^+ cells but not in Tie-2^-, Lineage^-, c-Kit^+, Sca1^+ cells. Applications Reported: The TEK4 antibody has been reported for use in flow cytometric analysis. Applications Tested: This TEK4 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Specifications

Specifications

CD202b (TIE2)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q02858
IgG1 κ
Affinity chromatography
Antibody
TEK4
Flow Cytometry
Biotin
Rat
Mouse
21687
Primary
4° C, store in dark, DO NOT FREEZE!
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