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CD172a (SIRP alpha) Rat anti-Mouse, APC, Clone: P84, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1721-82

Additional Details : Weight : 0.25000kg

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Product Code. 15390690

  • 276.08 EUR / 100µg


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Disclaimers:

For Research Use Only.


Description

Description

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.
Specifications

Specifications

CD172a
P84
APC
Conjugated
Rat
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
SHPS-1, Signal-regulatory protein alpha-1
IgG1
RUO
Primary
Murine
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