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CD163, Biotin, clone: eBioGHI/61 (GHI/61), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-1639-82

Additional Details : Weight : 0.25000kg

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Product Code. 15279749

  • 177.00 EUR / 100µg


Estimated Shipment date
from Supplier 28-12-2018
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Description

Description

Description: The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.Applications Reported: This eBioGHI/61 (GHI/61) antibody has been reported for use in flow cytometric analysis.Applications Tested: This eBioGHI/61 (GHI/61) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 μg This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD163
Monoclonal
0.5mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q86VB7
CD163 antigen, hemoglobin scavenger receptor, macrophage-associated antigen, scavenger receptor cysteine-rich type 1 protein M130
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
eBioGHI/61 (GHI/61)
Biotin
CD163
Liquid
CD163
IgG1, kappa, kappa
100μg
Store at 2-8°C. Do not freeze.
Primary
9332
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