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CD135 (Flt3) Rat anti-Mouse, Clone: A2F10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1351-85

Additional Details : Weight : 0.01000kg

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Product Code. 15257217

  • 217.00 EUR / 500µg


Estimated Shipment date
from Supplier 25-07-2019
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Description

Description

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Specifications

Specifications

CD135 (Flt3)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q00342
RP11-153M24.3, CD135, FLK2, STK1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Immunoprecipitation
A2F10
Unconjugated
Flt3
Liquid
Flt3
IgG2a, kappa
500 μg
4° C
Primary
14255
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For Research Use Only.