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CD127, clone: A7R34, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-1271-85

Additional Details : Weight : 0.01000kg

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Product Code. 15287197

  • 327.00 EUR / 500µg


Estimated Shipment date
from Supplier 03-06-2019
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Description

Description

Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Specifications

Specifications

CD127
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P16872
CD127, IL-7Ralpha, MGC107557
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization
A7R34
Unconjugated
Il7r
Liquid
Il7r
IgG2a, kappa
500 μg
4° C
Primary
16197
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