c-Met Rat anti-Mouse, PE, Clone: eBioclone 7, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 12-8854-80
Additional Details : Weight : 0.25000kg
DescriptionExcitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|AUTS9, HGFR, RCCP2, c-Met|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.