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Proteintech™ Human PD1 ELISA Kit

Solid phase sandwich ELISA used to detect and quantify protein levels of endogenous PD1

Brand:  Proteintech™ KE00075-96T


Product Code. 16891486

  • 269.00 EUR / 96 tests
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Description

Description

  • Recognizes human PD1
  • PD1 (Programmed cell death 1, CD279) is an immunoinhibitory receptor that belongs to CD28/CTLA-4 subfamily of Ig superfamily
    • Is a 288 amino acid Type I transmembrane protein composed of one Ig superfamily domain, stalk, transmembrane domain and intracellular domain containing an ITIM and ITSM
    • Expressed on T cells, B cells, natural killer T cells, activated monocytes, dendritic cells
    • Engagement by ligands transduces a signal that inhibits T cell proliferation, cytokine production and cytolytic function
    • Critical for regulation of T cell function during tolerance, autoimmunity and infection
    • Blockade of PD1 can overcome immune resistance and shown to have antitumor activity

Process:

  • Antibody specific for PD1 pre-coated onto microwells
  • PD1 protein in samples captured by the coated antibody after incubation
  • After extensive washing, another antibody specific for PD1 is added to detect captured PD1 protein
  • For signal development, horseradish peroxidase (HRP)-conjugated antibody is added, followed by Tetramethyl-benzidine (TMB) reagent
  • Solution containing sulfuric acid used to stop color development and color intensity
    • Proportional to quantity of bound protein, measurable at 450 nm with correction wavelength set at 630 nm
Specifications

Specifications

NP_005009
43 pg/mL
Sandwich ELISA, Double Antibody
Plasma, Serum
Human
Human
<10%
Blue ice
3.5 hr.
125 to 8000 pg/mL
ISO 13485
Coated ELISA Kit
DAB
5133
Solid
<10%
-20°C to +4°C
Q15116
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Safety and Handling

Safety and Handling

Product Identifier
  • 96TEST Human PD1 ELISA Kit

Signal Word
  • Warning

Hazard Category
  • Serious eye damage/eye irritation Category 1
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3

Hazard Statement
  • H302-Harmful if swallowed.
  • H315-Causes skin irritation.
  • H318-Causes serious eye damage.
  • H319-Causes serious eye irritation.
  • H332-Harmful if inhaled.
  • H335-May cause respiratory irritation.

Precautionary Statement
  • P201-Obtain special instructions before use.
  • P202-Do not handle until all safety precautions have been read and understood.
  • P234-Keep only in original container.
  • P264-Wash skin thoroughly after handling.
  • P270-Do not eat, drink or smoke when using this product.
  • P273-Avoid release to the environment.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
  • P330-Rinse mouth.
  • P362-Take off contaminated clothing.
  • P405-Store locked up.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information
  • MIXTURE LIST-Contains : Sulphuric Acid, Tetramethylbenzidine

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